We recently looked at the way "FEW" is used in Yes No Not Given questions.
'LITTLE' is used the same way.
Try the question below about the way pharmaceutical companies sell their products to doctors (Doctoring Sales).
Is Q10 True, False or Not Given (Yes, No, Not Given) according to Paragraph D?
Q10 The information provided by drug companies is of little use to doctors.
Paragraph D:
Salespeople provide much-needed information and education to physicians. In many cases the glossy brochures, article reprints and prescriptions they deliver are primary sources of drug education for healthcare givers.
.
.
.
.
.
.
Answer:
NO (FALSE). The opposite of 'little' is 'much' in this context - salespeople are the PRIMARY sources of education.
Notice the synonyms for 'doctors': physicians, healthcare givers.